Nijmegen Institute for Scientist-Practitioners in Addiction

Alcohol dependence and anxiety increase error-related brain activity.

TitelAlcohol dependence and anxiety increase error-related brain activity.
PublicatietypeJournal Article
Jaar van publicatie2010
AuteursSchellekens A, de Bruijn ERA, van Lankveld CAA, Hulstijn W, Buitelaar JK, DeJong CA, Verkes RJ
Publicatiedatum2010 Nov
TrefwoordenAdolescent, Adult, Alcoholism, Anxiety, Anxiety Disorders, Case-Control Studies, Electroencephalography, Evoked Potentials, Gyrus Cinguli, Humans, Impulse Control Disorders, Male, Middle Aged, Neuropsychological Tests, Personality Assessment, Reaction Time, Young Adult

AIMS: Detection of errors is crucial for efficient goal-directed behaviour. The ability to monitor behaviour is found to be diminished in patients with substance dependence, as reflected in decreased error-related brain activity, i.e. error-related negativity (ERN). The ERN is also decreased in other psychiatric disorders with impaired response inhibition, such as attention-deficit hyperactivity disorder and borderline personality disorder, but increased in anxiety disorders. The objective of the current study was to assess error monitoring in alcohol-dependent patients in relation to psychiatric comorbidity. We expected decreased error monitoring in alcohol-dependent patients with impulse control disorders and increased error monitoring in anxious alcohol-dependent patients. DESIGN: In a case-control design alcohol-dependent patients were compared with healthy controls. SETTING AND PARTICIPANTS: A consecutive series of 29 male alcohol-dependent patients, between 18 and 55 years of age, applying for in-patient detoxification were recruited at Novadic Kentron Center for Addiction Treatment. Fifteen age-matched healthy controls were recruited through advertisements in regional newspapers. MEASUREMENTS: Event-related potentials were recorded while performing a speeded choice-reaction task, from which ERN amplitudes were calculated. Axis-I and -II psychiatric comorbidity were assessed using the MINI International Neuropsychiatric Interview and the Structured Interview for DSM-IV Personality disorders. All participants completed the Temperament and Character Inventory and Profile of Mood States. FINDINGS: ERN amplitudes were increased for alcohol-dependent patients compared to healthy controls, particularly in patients with comorbid anxiety disorders. CONCLUSIONS: Increased error monitoring in alcohol-dependent patients, particularly those with comorbid anxiety disorders, is in contrast with previous studies that suggested decreased error monitoring to be a general feature in substance use disorders. Psychiatric disorders co-occurring with alcohol dependence, such as anxiety disorders, may indicate subpopulations of alcohol-dependent patients, with distinct neurobiological and genetic characteristics, possibly requiring different treatment strategies.

Alternatieve uitgaveAddiction
PubMed ID20840190