Nijmegen Institute for Scientist-Practitioners in Addiction

Baclofen and γ-Hydroxybutyrate (GHB), a Dangerous Combination.

TitelBaclofen and γ-Hydroxybutyrate (GHB), a Dangerous Combination.
PublicatietypeJournal Article
Jaar van publicatie2015
AuteursKamal RM, Qurishi R, DeJong CA
UitgaveJ Addict Med
Publicatiedatum2015 Jan-Feb

Baclofen is a γ-aminobutyric acid (GABA)-β receptor agonist with a muscle relaxant effect. It increases GABA activity and reduces the production of glutamate and dopamine. The GABA precursor γ-hydroxybutyrate (GHB) has gained popularity as a drug of abuse. For the first time, we report a case of a GHB-dependent patient, who ingested several days' doses of baclofen (80 mg) simultaneously with 0.3 L (215 g) of illicit GHB. Baclofen (40 mg/d) was prescribed to prevent relapse after a successful detoxification. The patient developed a rapid coma (E2M5V1 with oxygen support), bradypnea, and hypotonia. Physicians should be alert to the danger of this combination because of the hazards of coma and respiratory distress.

Alternatieve uitgaveJ Addict Med
PubMed ID25494007