NISPA

Nijmegen Institute for Scientist-Practitioners in Addiction

Effects of newer atypical antipsychotics on autonomic neurocardiac function: a comparison between amisulpride, olanzapine, sertindole, and clozapine.

TitelEffects of newer atypical antipsychotics on autonomic neurocardiac function: a comparison between amisulpride, olanzapine, sertindole, and clozapine.
PublicatietypeJournal Article
Jaar van publicatie2001
AuteursAgelink MW, Majewski T, Wurthmann C, Lukas K, Ullrich H, Linka T, Klieser E
UitgaveJ Clin Psychopharmacol
Volume21
Nummer1
Pagina's8-13
Publicatiedatum2001 Feb
ISSN0271-0749
TrefwoordenAdult, Antipsychotic Agents, Autonomic Nervous System, Benzodiazepines, Clozapine, Electrocardiography, Female, Heart, Heart Rate, Humans, Imidazoles, Indoles, Male, Middle Aged, Pirenzepine, Prospective Studies, Sulpiride
Samenvatting

As part of a prospective clinical study investigating the effects of atypical neuroleptics on autonomic neurocardiac function (ANF), serial standardized recordings of conventional electrocardiograms and computer-calculated measurements of 5-minute resting heart rate variability (HRV) were obtained from 51 medication-free inpatients with schizophrenia (DSM-III-R-diagnosed) before and after an average of 14.1 days of treatment with amisulpride 400 mg/day (N = 12), olanzapine 20 mg/day (N = 13), sertindole 12 mg/day (N = 13), or clozapine 100 mg/day (N = 13). Reference values for the HRV data were obtained from a large group of well-matched healthy controls (N = 70). The most important findings were the following: (1) clozapine, olanzapine, and sertindole all prolonged mean frequency-corrected QTc times, which, in the case of sertindole, proved to be significant (Wilcoxon test p <0.05); (2) sertindole and clozapine significantly increased the mean resting heart rate; and (3) only clozapine significantly reduced the parasympathetic resting tone. The results of the HRV studies are discussed considering the in vitro receptor profiles of the atypical neuroleptics under study. Potential implications for the cardiac safety and tolerance of these drugs are also discussed.

Alternatieve uitgaveJ Clin Psychopharmacol
PubMed ID11199953