Nijmegen Institute for Scientist-Practitioners in Addiction

Functional connectivity alterations in brain networks relevant to self-awareness in chronic cannabis users.

TitelFunctional connectivity alterations in brain networks relevant to self-awareness in chronic cannabis users.
PublicatietypeJournal Article
Jaar van publicatie2014
AuteursPujol J, Blanco-Hinojo L, Batalla A, López-Sola C, Harrison BJ, Soriano-Mas C, Crippa JA, Fagundo AB, Deus J, de la Torre R, Nogué S, Farré M, Torrens M, Martin-Santos R
UitgaveJ Psychiatr Res
Publicatiedatum2014 Apr
TrefwoordenAnxiety, Awareness, Brain, Brain Mapping, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Marijuana Abuse, Memory Disorders, Neural Pathways, Neuropsychological Tests, Oxygen, Psychiatric Status Rating Scales, Young Adult

BACKGROUND: Recreational drugs are generally used to intentionally alter conscious experience. Long-lasting cannabis users frequently seek this effect as a means to relieve negative affect states. As with conventional anxiolytic drugs, however, changes in subjective feelings may be associated with memory impairment. We have tested whether the use of cannabis, as a psychoactive compound, is associated with alterations in spontaneous activity in brain networks relevant to self-awareness, and whether such potential changes are related to perceived anxiety and memory performance.

METHODS: Functional connectivity was assessed in the Default and Insula networks during resting state using fMRI in 28 heavy cannabis users and 29 control subjects. Imaging assessments were conducted during cannabis use in the unintoxicated state and repeated after one month of controlled abstinence.

RESULTS: Cannabis users showed increased functional connectivity in the core of the Default and Insula networks and selective enhancement of functional anticorrelation between both. Reduced functional connectivity was observed in areas overlapping with other brain networks. Observed alterations were associated with behavioral measurements in a direction suggesting anxiety score reduction and interference with memory performance. Alterations were also related to the amount of cannabis used and partially persisted after one month of abstinence.

CONCLUSIONS: Chronic cannabis use was associated with significant effects on the tuning and coupling of brain networks relevant to self-awareness, which in turn are integrated into brain systems supporting the storage of personal experience and motivated behavior. The results suggest potential mechanisms for recreational drugs to interfere with higher-order network interactions generating conscious experience.

Alternatieve uitgaveJ Psychiatr Res
PubMed ID24411594