Nijmegen Institute for Scientist-Practitioners in Addiction

Genetic imaging consortium for addiction medicine: From neuroimaging to genes.

TitelGenetic imaging consortium for addiction medicine: From neuroimaging to genes.
PublicatietypeJournal Article
Jaar van publicatie2016
AuteursMackey S, Kan K-J, Chaarani B, Alia-Klein N, Batalla A, Brooks S, Cousijn J, Dagher A, de Ruiter M, Desrivieres S, Ewing SWFeldstei, Goldstein RZ, Goudriaan AE, Heitzeg MM, Hutchison K, Li C-SR, London ED, Lorenzetti V, Luijten M, Martin-Santos R, Morales AM, Paulus MP, Paus T, Pearlson G, Schluter R, Momenan R, Schmaal L, Schumann G, Sinha R, Sjoerds Z, Stein DJ, Stein EA, Solowij N, Tapert S, Uhlmann A, Veltman D, van Holst R, Walter H, Wright MJ, Yücel M, Yurgelun-Todd D, Hibar DP, Jahanshad N, Thompson PM, Glahn DC, Garavan H, Conrod P
UitgaveProg Brain Res

Since the sample size of a typical neuroimaging study lacks sufficient statistical power to explore unknown genomic associations with brain phenotypes, several international genetic imaging consortia have been organized in recent years to pool data across sites. The challenges and achievements of these consortia are considered here with the goal of leveraging these resources to study addiction. The authors of this review have joined together to form an Addiction working group within the framework of the ENIGMA project, a meta-analytic approach to multisite genetic imaging data. Collectively, the Addiction working group possesses neuroimaging and genomic data obtained from over 10,000 subjects. The deadline for contributing data to the first round of analyses occurred at the beginning of May 2015. The studies performed on this data should significantly impact our understanding of the genetic and neurobiological basis of addiction.

Alternatieve uitgaveProg. Brain Res.
PubMed ID26822360
PubMed Central IDPMC4820288
Grant List1P20GM103644-01A1 / GM / NIGMS NIH HHS / United States
1R21DA038381 / DA / NIDA NIH HHS / United States
P50 DA016556 / DA / NIDA NIH HHS / United States
PL1 DA024859 / DA / NIDA NIH HHS / United States
U54 EB 020403 / EB / NIBIB NIH HHS / United States
U54 EB020403 / EB / NIBIB NIH HHS / United States
UL1 DE019586 / DE / NIDCR NIH HHS / United States
UL1 RR024925 / RR / NCRR NIH HHS / United States