NISPA

Nijmegen Institute for Scientist-Practitioners in Addiction

The dopamine agonist apomorphine differentially affects cognitive performance in alcohol dependent patients and healthy controls.

TitelThe dopamine agonist apomorphine differentially affects cognitive performance in alcohol dependent patients and healthy controls.
PublicatietypeJournal Article
Jaar van publicatie2009
AuteursSchellekens A, van Oosterwijck AWAA, Ellenbroek B, DeJong CA, Buitelaar JK, Cools AR, Verkes RJ
UitgaveEur Neuropsychopharmacol
Volume19
Nummer1
Pagina's68-73
Publicatiedatum2009 Jan
ISSN1873-7862
TrefwoordenAdult, Alcoholism, Apomorphine, Cognition, Diagnosis, Dual (Psychiatry), Dopamine, Dopamine Agonists, Female, Humans, Male, Mental Disorders, Middle Aged, Psychomotor Performance, Reaction Time, Receptors, Dopamine, Socioeconomic Factors
Samenvatting

BACKGROUND: Reduced metabolic activity in frontal brain regions, and reduced striatal dopamine receptor densities have been shown in alcohol dependent patients. Little is known on functional changes in the fronto-striatal-thalamic dopaminergic neurocircuitry in these patients. The objective of this study was to assess sensitivity of prefrontal dopamine receptors in alcohol dependent patients. EXPERIMENTAL PROCEDURES: Male alcohol dependent patients (N=40) and healthy controls (N=39) performed an AX-continuous performance test before and after administration of the DA agonist apomorphine (0.005 mg/kg). RESULTS: At baseline alcohol dependent patients were slower and less accurate compared to healthy controls. After administration of apomorphine, performance improved in alcohol dependent patients and deteriorated in healthy controls. CONCLUSIONS: Reduced cognitive performance in alcohol dependent patients compared with healthy controls may indicate dopamine dysfunctioning at the prefrontal level. Improvement of cognitive performance in alcohol dependent patients after administration of apomorphine and deterioration in healthy controls provides evidence for an inverted U-shape relation between dopaminergic functioning and cognitive performance.

DOI10.1016/j.euroneuro.2008.08.006
Alternatieve uitgaveEur Neuropsychopharmacol
PubMed ID18829269