NISPA

Nijmegen Institute for Scientist-Practitioners in Addiction

Treatment effects of serotonergic and noradrenergic antidepressants on the intensity dependence of auditory ERP components in major depression.

TitelTreatment effects of serotonergic and noradrenergic antidepressants on the intensity dependence of auditory ERP components in major depression.
PublicatietypeJournal Article
Jaar van publicatie2009
AuteursLinka T, Sartory G, Wiltfang J, Müller BW
UitgaveNeurosci Lett
Volume463
Nummer1
Pagina's26-30
Publicatiedatum2009 Sep 29
ISSN1872-7972
TrefwoordenAdrenergic Uptake Inhibitors, Adult, Antidepressive Agents, Citalopram, Depressive Disorder, Major, Evoked Potentials, Auditory, Female, Humans, Male, Middle Aged, Morpholines, Serotonin Uptake Inhibitors
Samenvatting

The intensity dependent amplitude change of auditory evoked potentials (IDAP), an assumed indicator of the level of central nervous serotonergic neurotransmission, was measured in major depressive disorder (MDD, DSM-IV: 296.2, 296.3; APA 1994) before and after treatment with either a selective serotonin reuptake inhibitor or a selective noradrenaline reuptake inhibitor antidepressant and compared with the results of a healthy control group. Auditory evoked P1, N1, P2, P1/N1 and N1/P2 peak-to-peak amplitudes were evaluated in 26 in-patients with MDD prior to and after antidepressant treatment with citalopram (24 days, n=14) or reboxetine (25 days, n=12), and in 43 healthy control subjects. Clinical symptoms of MDD were assessed by means of standardized psychiatric rating scales (CGI, HDRS, HAMA and BDI). The IDAP within the control group remained stable over 24 days (N1 amplitude slope retest ANOVA p=.79). Neither applied antidepressants nor decrease of HDRS total score during treatment had a significant effect on the IDAP in the patients' sample. The conclusion that the IDAP does not reflect the temporary depressive state in MDD is discussed.

DOI10.1016/j.neulet.2009.07.038
Alternatieve uitgaveNeurosci. Lett.
PubMed ID19616062